Prof. Facundo Manes

Dr. Manes obtained his medical degree from the School of Medicine at the University of Buenos Aires, Argentina and his Master of Philosophy and his PhD of Sciences from the University of Cambridge, England. As a medical student, he received the “Neurociencias 1992” award, granted by the Argentine Medical Association for his research work entitled “The role of the corpus callosum in interhemispheric cerebral transfer”. During his medical education, he was an anatomy instructor at the School of Medicine and the School of Pharmacy and Biochemistry at the University of Buenos Aires.

He completed his residency program in Neurology at the Raúl Carrea Institute for Neurological Research (FLENI) and trained in Functional Neuroimaging in the Department of Neuroradiology, Massachusetts General Hospital (Boston, USA), also completing a fellowship in neuropsychiatry in the Department of Psychiatry, University of Iowa (Iowa City, USA), where he was also a neuroanatomy instructor. He worked as a neurologist and clinical investigator in the Departments of Neurology and Psychiatry, at the University of Cambridge, and is currently a consultant in Neurology and Neuropsychology in the Medical Research Council Cognition (MRC) Cognition and Brain Sciences Unit, University of Cambridge.

Once he finished his postgraduate study abroad in the United States and England, he returned to Argentina determined to develop local resources in order to raise clinical and research standards in cognitive neuroscience, cognitive neurology and neuropsychiatry. Dr Manes has been instrumental in developing cognitive neuroscience in Argentina and in South America. He was initially the head of the Cognitive Neurology, Neuropsychology and Neuropsychiatry Section at the Raul Carrea Institute for Neurological Research (FLENI). He then founded INECO (The Institute of Cognitive Neurology) and the Institute of Neurosciences at Favaloro University in Buenos Aires. These institutions are considered state-of-the-art leading institutions in the field of neurosciences throughout Latin America and have become internationally recognized clinical research centers.

Dr. Manes has published over 240 original scientific works in the most prestigious international journals of his field, such as Neurology, Brain, JAMA Neurology, The Lancet Neurology and Nature Neuroscience. His h-index is 74 and his work has received over 23359 citations to date (Google Scholar), an outstanding level of recognition by any standard. Besides, he has contributed numerous chapters in English and Spanish for international books on neurology and psychiatry including Kaplan & Sadock’s Comprehensive Textbook of Psychiatry (Williams & Wilkins), Behaviour and Mood Disorders in Focal Brain Lesions (Cambridge University Press), Neuropsychology of Emotion (Oxford University Press), Hodges’ Frontotemporal Dementia, 2nd Edition (Cambridge University Press), Oxford Textbook of Cognitive Neurology and Dementia (Oxford University Press), Handbook of Clinical Neurology, 3rd edition (Elsevier 2015) among others. Dr Manes has written eleven books, namely “Convivir con personas con Alzheimer u otras Demencias” (Living with Alzheimer’s & Other Dementias); “Tratado de Neuropsicología” (Handbook of Neuropsychology); “Social Neuroscience of Psychiatric Disorders”; “Usar el Cerebro: Conocer nuestra mente para vivir mejor” (Use your brain: Understanding our mind for a better standard of life), “El Cerebro Argentino: Una manera de pensar, dialogar, y hacer un país mejor” (The Argentinean Brain, a way of thinking, discussing, and making a better country), “Descubriendo el Cerebro” (Discovering the Brain) “El Cerebro del Futuro” (The Brain of the Future), “Cerebros en construcción” (Brains in construction) “Decir presente. Hacer futuro. La revolución del conocimiento como motor del proyecto argentino” (Say present, Make future. Knowledge revolution as the engine of the Argentine project), and recently Ser Humanos (being Human)

Dr. Manes frequently gives lectures around the world in international scientific forums. He was a consultant for Health and Education of the Dana Foundation in New York. Facundo Manes is a reviewer of numerous international scientific journals, including Brain, Journal of Neurology Neurosurgery and Psychiatry, Journal of Neurology, Journal of Alzheimer’s Disease, Neuropsychology, Social Neuroscience, Neurology, Psychological Medicine, CNS Spectrums, JINS, CORTEX, American Journal of Psychiatry, Schizophrenia Research, Behavioural Neurology, Human Brain Mapping, Journal of Clinical and Experimental Neuropsychology, Brain Structure and Function, Behavioral Neurology, Journal of Nervous and Mental Disease, Neuropsychology, Cortex, Neurology, Frontiers Neuroscience, Frontiers in Aging Neuroscience, Frontiers in Dementia, Journal of Alzheimer’s Disease, and Neuroimage, among others.

He is also a scientific reviewer for universities, government organizations, and research foundations. Dr. Manes is a member of the editorial board of the Neuropsychological Rehabilitation journal, a member of the Editorial Board of Current Psychiatry Reports, and an Associate Editor for Frontiers in Dementia, Frontiers in Aging Neuroscience, and Frontiers in Neuroscience for Young Minds (Nature Publishing Company).

He has been distinguished with leading national and international awards, including the Training High-Level Human Resources, granted by the Argentine Ministry of Education, the “Arturo Jauretche” award for his contribution to the national thinking, the Young Investigator Award 1999 granted by the American Neuropsychiatric Association. He was recognized by the Buenos Aires Legislature as an “Illustrious Citizen” of the City of Buenos Aires, Argentina, the Ordine Della Stella D’Italia and received the Honorable Mention “Senator Domingo Faustino Sarmiento”, the Argentinean Senate highest award, in recognition for his outstanding and invaluable service to the community.

Facundo Manes is a member of several national and international scientific societies. He is a past advisory international board member of the ICD-11 Expert Working Group on the Classification of Neurocognitive Disorders of the World Health Organization. Dr. Manes also contributed to the revision of the clinical diagnostic criteria for the primary progressive aphasias (published in Neurology, 2011) and for the behavioral variant of frontotemporal dementia (published in Brain, 2011) proposed by an international working group. He is currently the principal investigator or co-principal investigator on several trials evaluating potential new therapies in Alzheimer’s disease.

Within the realm of clinical neuroscience, Facundo Manes has contributed widely, but particularly to studies of disorders of executive function, consciousness and memory. He has numerous productive collaborations throughout the world. In particular, Dr. Manes’ work on decision making, emotion processing, and social cognition in psychiatric disorders has received critical acclaim. Among his specific contributions, Dr. Manes has identified, together with Prof. Robbins and Sahakian the prefrontal areas related to the decision-making processes; together with Dr. Calder, he has described the neural basis of anger, and the role of the insula in emotional and cognitive processes. Furthermore, he has described, for the first time, emotional processing in the minimally conscious state with Dr. Bekinschtein. He has proposed, together with Dr. Ibáñez, a theory of the neural substrates of the specific pattern of social cognition impairment seen in several neuropsychiatric disorders. He has also developed the first cognitive rehabilitation unit in Latin America using a holistic approach. His current research focuses on the neurobiology of mental processes, particularly the role of the prefrontal cortex in decision-making and social cognition. He is supervising Ph.D. students and postdoctoral students in different projects involving executive functions, decision making, and social cognition in neuropsychiatric disorders. His team has also focused on the development of ecological and highly demanding executive tasks as well as screening tests for the early detection of neuropsychological impairment in different types of cognitive disorders.

He has played a central role in increasing awareness of the dementia epidemic in South America (i.e: see his publication on the topic in Lancet Neurology). Facundo Manes strongly believes in promoting neuroscience among society. He hosted “Los Enigmas del Cerebro” (Mysteries of the Brain), a TV show that aired in Argentina during 2011, “Cerebro Argentino” in 2014, and “The Super Brain” HD Documentary 2015 (Discovery Science Channel). Dr. Manes also writes regularly for the general public on topics of the brain, cognition, and dementia (i.e: he is a columnist in “El Pais”, the world’s most influential Hispanic newspaper). He is a vocal advocate for science and education in society. He has written a book about the brain accessible to the general public which is a bestseller in Latin America and Spain.

Currently, Dr. Manes is principal investigator of the National Scientific and Technical Research Council (CONICET) in Argentina, past President of the International Frontotemporal Dementia Society, and Founder of the INECO Foundation for Research in Neuroscience (Buenos Aires, Argentina). The INECO Foundation is a non-profit organization, the purpose of which is to support research programs for the prevention, diagnosis, and treatment of neurological and psychiatric disorders. INECO Foundation also promotes the scientific training of health professionals and raises awareness in the community about issues related to neurology and psychiatry. Dr. Manes is also a consultant in the Medical Research Council (MRC) Cognition and Brain Sciences Unit, University of Cambridge.

He is the past president of the World Federation of Neurology Research Group for Aphasia, Dementia and Cognitive Disorders and former Partner Investigator of the Australian Research Council (ARC) Centre of Excellence in Cognition and its Disorders.

Dr. Manes is a Professor of Neurology, Behavioral Neurology, and Cognitive Neuroscience at the Favaloro University of Buenos Aires, Argentina. He was the former president of the Favaloro University. Dr Manes has been a Professor at the University of South Carolina (USA), at Macquarie University (Sydney, Australia), and Visiting Professor at the Department of Neurology at the University of California, San Francisco (UCSF, USA).

Despite his numerous commitments, Dr. Manes remains involved in clinical practice and teaching. He maintains a busy clinic at INECO and provides guidance and training to young clinicians and scholars through his mentoring and supervision and his teaching at Favaloro University, as well as multiple invitations to speak. This demonstrates his engagement and commitment to ensure that the next generation of neurologists and neuroscientists can benefit from his vast experience.

He and his team have created the first “Behavioral Insight and Neuroscience Unit” for social protection and health policies in Latin America to foster improvements in the most critical lifespan stages: early childhood and aging. This Behavioral Insight Group offers innovative approaches to solve health and social problems (such as poverty and malnutrition) in Latin America.

He has fostered the Mental Capital and Wellbeing Delivery report, the first government platform in Argentina to develop evidence-based interventions, articulate existing policy initiatives from multiple government agencies, and advocate the importance of long-term investment in the development of cognitive, social, and emotional skills throughout the different stages in life.

In 2018 he created a center for neurorehabilitation in the heart of Buenos Aires. This institute also supports entrepreneurs in fields related to science and technology in an “antidisciplinary” culture ecosystem.

Besides his contribution to medicine and science, Dr. Manes is deeply involved in disseminating the importance of knowledge in Latin America. Since December 2021, he is a national Congressman and the President of the Committee on Science, Innovation, and Technology of the Argentinian Parliament. His commitment is to work towards a long-term vision based on the idea that the wealth of a country is measured through the value of human capital, education, science and technology; and that in said factors lies the basis of social development. He also believes science has something to contribute to politics. The more solid the bridge between science and state decisions, the closer we will be to a democratic, modern and developed society.